Monday, June 17, 2013

Patients with HCV, occult HBV at greater risk for mortality, HCC, cirrhosis

Patients coinfected with chronic hepatitis C and occult hepatitis B were more likely to develop cirrhosis or hepatocellular carcinoma and had poorer survival than patients with hepatitis C alone in a recent study.

In an observational cohort study, researchers tested 326 patients with chronic HCV for occult HBV infection (OBI) between 1991 and 2000. All participants were hepatitis B surface antigen (HBsAg)-negative and underwent liver biopsy. Follow-up for a median of 11 years (range 5-19 years) was performed in 94 patients, including 37 OBI-positive and 57 OBI-negative participants.


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