An article in the Chinese Medical Journal that
compares the causes of cirrhosis today vs. 18 years ago in Beijing
interesting snapshot of social change and the power of immunization
The study of 2,119 Beijingers (one-third female) found that
liver scarring has declined from 75.2% to 48.7%, but alcoholic liver
disease increased from 5.1% to 10.6%. Among women, cirrhosis related
to hepatitis C and auto-immune liver
disease have increased.
—Christine. M. Kukka, Project Manager, HBV Advocate
features of cirrhosis ...", by Song,
Feng, Rao et al. Chinese Medical Journal. 2013
The etiological spectrum of cirrhosis has changed over the
years, but our knowledge of it is limited. The present study
aimed to investigate the etiological features of cirrhosis
inpatients and their variation in the past 18 years in Beijing.
A retrospective analysis was performed on all patients with
cirrhosis diagnosed for the first time in Peking University
People's Hospital from January 1, 1993, to October 25, 2010.
Data were analyzed using SPSS 20.0.
A total of 2119 cirrhosis inpatients were included in this
study: 1412 (66.6%) male and 707 (33.4%) female. Chronic hepatitis B accounted for
58.7%; chronic hepatitis C for 7.6%; chronic hepatitis B and hepatitis C
virus co-infection for 0.8% (16 cases); alcoholic liver disease
for 9.4% (200 cases); and autoimmune diseases for 9.4% (199
cases). In the past 18 years, the percentage of chronic hepatitis B has decreased
from 75.2% to 48.7%; alcoholic liver disease has increased from
5.1% to 10.6%; and autoimmune disease has increased from 2.2% to
12.9%. The percentages of chronic hepatitis B and alcoholic liver disease were
higher among men, whereas the percentages of chronic hepatitis
C, autoimmune diseases and cryptogenic cirrhosis were higher
Chronic hepatitis B was
still the most common etiology of cirrhosis in China, but the
percentage has been decreasing. The percentages of alcoholic
liver disease and autoimmune diseases have been increasing. The
etiological spectrum of cirrhosis inpatients differed
significantly according to sex.
Labels: alcoholic liver disease, China, cirrhosis, epidemiology