Tuesday, September 3, 2013

Decompensated cirrhosis increases risk of liver cancer for people with HIV and viral hepatitis co-infection

Decompensated cirrhosis increases risk of liver cancer for people with HIV and viral hepatitis co-infection

There is a relatively low incidence of hepatocellular carcinoma (HCC) among people living with HIV who have liver cirrhosis, results of a prospective Spanish study published in the online edition of the Journal of Acquired Immune Deficiency Syndromes show. During five years of follow-up, the overall incidence was 6.72 per 1000 person-years. But incidence was significantly higher among the participants with decompensated cirrhosis at the start of the study compared to participants with compensated cirrhosis. All the study participants had hepatitis C virus (HCV) and/or hepatitis B virus (HBV) co-infection.

“An important finding of our study was a clear trend towards a higher incidence of HCC among patients with decompensated cirrhosis as compared with those with compensated cirrhosis,” comment the authors.

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