Thursday, January 2, 2014

Scientists Decipher How the Immune System Induces Liver Damage During Hepatitis

Viral infections are the primary cause of liver inflammation or hepatitis, affecting hundreds of millions of people all over the world, and they represent a public health problem worldwide. The acute condition can cause irreversible damage to the liver, and if not cured can become chronic, leading to serious diseases such as cirrhosis or cancer.

A study published in the online edition of The Journal of Clinical Investigation, and carried out by Erwin Wagner’s team, Director of the BBVA Foundation-­‐CNIO Cancer Cell Biology Programme and holder of an ERC Advanced Grant, shows how the immune system ‘attacks’ liver cells during hepatitis by using the AP-­‐1 gene JunB.

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