- High preoperative HBsAg level was associated with significantly poorer 5-year disease-free survival and overall survival in patients with low baseline HBV DNA.
- High HBsAg level was an independent predictor of hepatocellular carcinoma recurrence and mortality.
Disease-Free Survival and Overall Survival
The study was a retrospective analysis of 1,062 HBsAg-seropositive patients with low HBV DNA levels (< 200 IU/mL) who underwent partial hepatectomy for hepatocellular carcinoma. Median follow-up was 60 months. Risk of tumor recurrence increased with HBsAg levels ≥ 1,000 IU/mL. For patients with low (< 1000 IU/mL; n = 622) vs high (≥ 1,000 IU/mL, n = 440) HBsAg level, 5-year disease-free survival was 46.1% vs 34.1% (P = .002) and overall survival was 57.5% vs 48.8% (P = .004).