FibroTest yielded suboptimal accuracy in detecting significant fibrosis, cirrhosis

Nermin N. Salkic, MD, PhD, department of gastroenterology and hepatology, University Clinical Center Tuzla, Bosnia and Herzegovina, and colleagues included 16 studies with 2,494 patients after searching Medline, Embase and Cochrane Library databases. Studies were used in a hierarchical summary receiver operating curve model to determine the presence of liver fibrosis, while 13 of the studies (n=1,754) were included in a different hierarchical summary receiver operating curve model to assess liver cirrhosis.

“FibroTest is of excellent utility for excluding cirrhosis in patients with chronic hepatitis B,” Salkic told Healio.com/Hepatology. “The diagnostic performance of FibroTest in detection of significant fibrosis and cirrhosis and exclusion of significant fibrosis is suboptimal. It is important for clinicians to adhere to the recommended thresholds of FibroTest until better ones are derived.”

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