Patients
with hepatocellular carcinoma (HCC) that was related to hepatitis B
virus (HBV) infection were found to have more advanced clinicopathologic
features and worse outcomes compared with those with hepatitis C virus
(HCV)-related HCC, according to a retrospective analysis conducted on
historical data from patients treated at the MD Anderson Cancer Center.
"Hepatitis B HCC patients tended to have shorter overall survival and
time to progression regardless of systemic therapy, although the
difference was not statistically significant," Marc Uemura, MD, MBA,
fellow, hematology and medical oncology, MD Anderson Cancer Center, said
during a presentation of the results at the 2015 ASCO Annual Meeting.
In the study, single institution medical records for 815 patients with
viral-related HCC from 1992 to 2011 were reviewed. HCV was present in
472 patients (58%), while HBV was seen in 343 individuals (42%). Viral
status was confirmed by serology.
- See more at: http://www.targetedonc.com/publications/hcc-monitor/2015/july-2015/hepatitis-b-confers-worse-outcomes-more-advanced-disease#sthash.NEvhCq2e.dpufLabels: cancer survival, disease progresion, HCC